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. 2017 Oct 4;7:12649. doi: 10.1038/s41598-017-12650-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in refraction (Rx, the left Y-axis) and ocular component measures (vitreous chamber depth, VCD; choroidal thickness and axial length, AL, the right Y-axis) after lens wear for 3 and 7 days. The values are differences between d0 and d3 or d7. Right (R) eyes wore −10D lenses while left (L) eye wore +10D lenses. The refraction and ocular components were significantly changed between the right and left eyes after lens wear for both treatment time points (paired t-test, **p < 0.01, ***p < 0.001, n = 15).