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. 2017 Oct 4;7:12649. doi: 10.1038/s41598-017-12650-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The network generated by IPA of the identified proteins altered during myopic ocular growth. Proteins in the network are represented by their gene symbols [TF: ovotransferrin; APOA1: apolipoprotein A1; CST3: cystatin; RBP4/RBP: retinol binding protein (purpurin-like protein); HDL: high density lipoprotein; and LDL: low density lipoprotein]. Four up-regulated proteins identified by LCMS and their close interactions with lipid metabolism (HDL and LDL) are highlighted in red. The white nodes are those identified from the IPA Knowledge Base that may be associated to the identified proteins through specific interactions.