Fig. 6.

Nano-11 improves antigen targeting to immunopotentiating cells in the draining lymph node and increases retention of antigen at the injection site. a Expression of CD86 on different types of OVA⁺ cells in the lymph node. b Phenotyping of OVA⁺ and OVA⁻ MigDCs in the draining lymph node. Lymph nodes were harvested 2 days after injection of 10 μg Alexa Fluor 647-labeled OVA adjuvanted with 200 μg Nano-11 and data are representative of two independent experiments. c Mice were injected with 10 μg of Alexa Fluor 647-conjugated OVA alone or adjuvanted with either AH or Nano-11 and examined with a fluorescence imager over time. Data are representative of two independent experiments