Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 15;2:17. doi: 10.1038/s41541-017-0018-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Antibodies in mice immunized with Ty21a-PA01. Mice were vaccinated with 5 × 10⁷ CFU of Ty21a (triangles) or Ty21a-PA-01 (squares) by intraperitoneal (IP) injection at 2-week intervals. Sera collected at 2 weeks after dose 3 were assayed for anti-PA IgG by ELISA (a) and anthrax toxin neutralization activity (TNA) (b). Antibody responses by ELISA are reported as the serum dilution at which the optical density was 1.0 (OD 1.0), and TNA titers as the last serum dilution at which there was 50% protective activity against killing of macrophages (J774A.1) by LT. Filled symbols represent mice that were not protected in the spore challenge study and open symbols represent those that were protected (see Fig. 3). The geometric mean of each group is shown as a horizontal line. Antibody responses between the two groups were analyzed by Mann–Whitney U test (p = 1.1 × 10⁻⁵ and 8.2 × 10⁻⁶ for ELISA and TNA, respectively)