Fig. 4.

FluB DMAb protects mice from diverse lethal influenza B challenges. BALB/c mice were treated with FluB DMAb plasmid DNA 5 days prior to infection with B/Malaysia/2506/2004 Victoria (a–c) or B/Florida/4/2006 Yamagata (d–f) lineage virus. One day prior to infection, separate groups of mice received 0.03–1 mg/kg FluB protein monoclonal antibody i.p. a, d Human IgG in mouse sera at the time of infection. Dotted line indicates LOD (n = 10 animals per group, mean ± SD). b, e Kaplan–Meier survival curves of BALB/c mice challenged with influenza B (n = 10 animals per group, *p ≤ 0.0001 FluB DMAb versus Control DMAb). c, f Weight of BALB/c mice following influenza B challenge. Dotted line indicates 25% maximum weight loss. (n = 10 animals per group, mean ± SEM)