Table 2. Combined effects of cefazolin (CEZ) and nisin A determined by the checkerboard assay.
Organism | n | FIC index | No. of strains (%) |
|||
---|---|---|---|---|---|---|
Synergism | Additive | Indifferent | Antagonism | |||
(≤0.5) | ( >0.5 to ≤1.0) | ( >1.0 to ≤2.0) | ( >2.0) | |||
Staphylococcus aureus | 20 | 0.19–0.5 | 20 (100) | 0 (0) | 0 (0) | 0 (0) |
Staphylococcus intermedius | 20 | 0.19–1.0 | 8 (40) | 12 (60) | 0 (0) | 0 (0) |
Streptococcus agalactiae | 10 | 0.63–1.0 | 0 (0) | 10 (100) | 0 (0) | 0 (0) |
Streptococcus dysgalactiae | 18 | 0.56–1.0 | 0 (0) | 18 (100) | 0 (0) | 0 (0) |
Enterococcus faecalis | 18 | 0.19–1.0 | 13 (72.2) | 5 (27.8) | 0 (0) | 0 (0) |
Escherichia coli | 18 | 0.5 –1.0 | 4 (22.2) | 14 (77.8) | 0 (0) | 0 (0) |
The FIC index values were interpreted as follows: ≤0.5, synergistic; >0.5 to ≤1.0, additive; >1.0 to ≤2.0, indifferent; and >2.0, antagonistic effects.