Fig. 1.

KK-Ay mice were orally administered with 10H2DA (3 mg/kg in body weight in 25% ethanol) or vehicle (25% ethanol) for 4 weeks. A: No differences in body weight and food intake were observed between 10H2DA-treated and vehicle-treated mice (n=8). B: Blood glucose levels after 4 weeks of administration of 10H2DA or vehicle were measured during an OGTT in KK-Ay mice fasted overnight (n=6–8). C: Plasma insulin levels during the OGTT were determined in the mice (n=6). D: The HOMA-IR was calculated using the fasting glucose levels from Fig. 1B and insulin levels from Fig. 1C. Data are presented as the mean ± SEM. *P<0.05, **P<0.01 vs. vehicle.