. Author manuscript; available in PMC: 2017 Oct 4.

Published in final edited form as: Psychopharmacology (Berl). 2016 Feb 12;233(10):1945–1962. doi: 10.1007/s00213-016-4235-8

Table 3.

Effects of METH self-administration and withdrawal on transcriptional regulation in the rat striatum.

METH exposure regimen	METH intake	Time-points studied	Data obtained	Reference
2 hours/day for 3 weeks	4 ± 0.9 mg/kg/day	immediately after cessation of self-administration	↑c-Fos immunoreactivity	Cornish et al. 2012
2 hours/day for 3 weeks	4 ± 0.9 mg/kg/day	immediately after cessation of self-administration	↑FosB/ΔFosB immunoreactivity	Cornish et al. 2012
15 hours/day, 8 days	up to 14.0 mg/kg/day	2 hours	↑C-jun, ↑C-fos, ↑Fosb mRNA	Krasnova et al., 2013
15 hours/day, 8 days	up to 14.0 mg/kg/day		↑Creb, ↑Crem mRNA	Krasnova et al., 2013
			↑Stx1a, ↑Syn2, ↑Syp mRNA
			↑Bdnf, ↓Ngfg mRNA
			↑GABBR2, ↑KCNJ6, ↑HCRTR1 mRNA
			↑ΔFosB, ↑pCREB protein levels
		24 hours	↑Ngfg mRNA,
			↑NFAT-mediated signaling
			↑IL-6 signaling, ↑IL-10 signaling
			↑ΔFosB, ↑pCREB protein levels
		1 month	↓cFos, ↓ΔFosB protein levels
			↓CREB protein, ↓pCREB protein
9 hours/day, 10 days	up to 7 mg/kg/day	1 month	↑Fos, ↑Egr1, ↑Arc mRNA	Li et al., 2015
9 hours/day, 10 days	up to 7 mg/kg/day		↑Gria1, ↑Gria3, ↑Grin2a, ↑Grm1 mRNA	Li et al., 2015
			↑Bdnf, ↑Trkb mRNA
			↑Hdac3, ↑Hdac4, ↑Hdac5, ↑Dnmt3a mRNA
			↓Gria2 mRNA in Fos-positive striatal neurons