Figure 1.

Long-range correlations in DNA methylation are distinct among different cell classes. The Pearson correlation coefficients for chromosome 1 of different cells are shown in log-log plots. The average scaling exponents are annotated in the figure. (A) Eight different somatic cells: aorta, esophagus, fat, gastric, lung, psoas, small bowel, and spleen. (B) Nine different cancer cells: bladder urothelial carcinoma (blca), breast invasive carcinoma (brca), colon adenocarcinoma (coad), colorectal cancer (colon), lung adenocarcinoma (luad), lung squamous cell carcinoma (lusc), rectum adenocarcinoma (read), stomach adenocarcinoma (stad), and uterine corpus endometrial carcinoma (ucec). The cells are labeled after TCGA except for colorectal cancer (colon). (C) Normal brain cells of different ages (fetal, 35 days old, and 2–64 years old). (D) Three different gland cells (adrenal, ovary, and pancreas). Correlation for normal aorta cells (normal) is also plotted for comparison in (B), (C), and (D). To see this figure in color, go online.