Figure 2.

Heatmap clustering for the scaling exponents of all autosomal chromosomes shows differences between different cell classes. Sample labels are summarized in Supporting Material. (A) The scaling exponents of normal somatic cells are robust among three different individuals and the gland cells segregate from other cells. (B) Normal somatic cells (left to right: aorta to ucec_n5) segregate from cancer cells (brca_t1 to ucec_t5). luad_t5 and stad_n4 are further analyzed in Supporting Material. (C) Normal brain cells (fetal to 64 year) segregate from glioblastoma (GBM, gbm_t1 to gbm_t6) or NDDs (31_08 to w145). (D) ESCs and induced pluripotent stem cells (h1 to imr90_ipsc) segregate from cell lines including adult stem cell lines (ads) and somatic cell lines (ads_adipose, ff, and imr90). Normal somatic cells (aorta to spleen) were shown again for comparison. The chromosomes with correlations deviating from power law distributions are labeled with white forks (see Supporting Material for more analyses). To see this figure in color, go online.