Table 4.
GABBR1 DNA methylation | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Child HPA axis stress response | CpG_1.2 | CpG_3 | CpG_6 | CpG_8 | CpG_9.10 | CpG_11 | CpG_14.15 | CpG_16 | CpG_17 | Average GABBR1 | ||
2 M (n = 20) | AUCi | Pearson R | 0.372 | − 0.476 | 0.029 | − 0.452 | 0.109 | 0.062 | 0.375 | 0.238 | 0.218 | − 0.152 |
p value | 0.141 | 0.053 | 0.924 | 0.091 | 0.678 | 0.826 | 0.153 | 0.375 | 0.418 | 0.547 | ||
Initial response | Pearson R | 0.141 | − 0.47 | 0.092 | − 0.270 | 0.120 | − 0.004 | 0.448 | 0.125 | 0.172 | − 0.098 | |
p value | 0.565 | 0.043 | 0.745 | 0.295 | 0.624 | 0.989 | 0.062 | 0.621 | 0.494 | 0.680 | ||
Recovery slope | Pearson R | 0.141 | − 0.283 | 0.063 | − 0.162 | 0.118 | − 0.103 | 0.342 | − 0.012 | 0.083 | − 0.086 | |
p value | 0.576 | 0.255 | 0.830 | 0.550 | 0.641 | 0.716 | 0.179 | 0.964 | 0.751 | 0.727 | ||
4 M (n = 67) | AUCi | Pearson R | 0.260 | 0.239 | 0.241 | 0.200 | 0.084 | 0.096 | 0.080 | 0.186 | 0.082 | 0.168 |
p value | 0.041 | 0.079 | 0.091 | 0.150 | 0.538 | 0.487 | 0.553 | 0.177 | 0.547 | 0.189 | ||
Initial response | Pearson R | 0.392a | 0.215 | 0.35 | 0.3 | 0.166 | 0.184 | 0.077 | 0.160 | 0.136 | 0.202 | |
p value | 0.001 | 0.102 | 0.009 | 0.023 | 0.210 | 0.166 | 0.556 | 0.230 | 0.301 | 0.100 | ||
Recovery slope | Pearson R | 0.400a | 0.219 | 0.38 | 0.35 | 0.209 | 0.27 | 0.130 | 0.192 | 0.182 | 0.225 | |
p value | 0.001 | 0.102 | 0.005 | 0.010 | 0.115 | 0.047 | 0.327 | 0.159 | 0.173 | 0.071 |
aSignificant at the α level of 0.0019, corrected for 27 tests (3 cortisol variables and 9 CpG sites)