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(a) MAB04 inhibits IL-36 induced skin swelling in mice (b) MAB04 inhibits IL-36 induced production of Lipocalin2. Intradermal L-36 injection into ear of C57B/6 mice induced increases in ear thickness (swelling) and Lipocalin2 (LCN2) which was significantly inhibited by a single 250 µg i.p. injection of MAB04 before challenge. Mean +/− SEM. N = 8/group.
