Table 1.

Assessment of biophysical properties.

Mouse anti-huIL-36R lead antibodies	ka (M−1s−1)	kd (s−1)	KD (pM)	NCI/ADR-RES IC90 (nM)	Human primary dermal fibroblast IC90 (nM)
mMAB92	1.36 × 106	3.28 × 10−5	24	0.9	1.9
mMAB93	1.1 × 106	1.56 × 10−5	14	0.9	n.d.
mMAB94	1.53 × 106	2.38 × 10−5	16	1.3	n.d.
mMAB95	9.3 × 105	5.2 × 10−5	55	3.8	n.d.

n.d.: not determined