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Assessment of biophysical properties.
| Parameter |
MAB92 |
| Binding affinity by surface plasmon resonance (hIL-36R) | KD = 20 pM |
| Aggregation after 2-step purification process (% monomer) | 98 |
| pI as determined by isoelectric focusing | >8 |
| Thermal stability (DSC- Fab Tm)) | 76.1°C |
| Deamidation within the Fab (pH 9.0 @ 37°C for 1 week) | <5% |
| Whole blood stability (48 h at 37°C) | <2-fold |
| Valence at pH 5.0 | +21.7 |
| Solubility (mg/ml) | 127 |
