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. 2017 Aug 14;9(7):1076–1087. doi: 10.1080/19420862.2017.1364325

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© 2017 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 9. — Suggested decision tree during lead identification of bivalent and multivalent antibodies (Ab) for the determination of the relevant in vivo interaction mode and the identification of the candidate with the optimal binding strength. Check points involving the conversion of the bivalent and multivalent antibodies to Fabs are highlighted in green. *In the case of a monovalent target and an available assay excluding avidity (e.g., using the soluble monovalent target in solution), the Ab to Fab conversion may be omitted.