Table 3.

Significant PRCCs for inflammation outcomes. List of all the parameters/mechanisms (rows) that have a significant (i.e., p < 10⁻³) respect to outputs of the model that are directly related to inflammation (columns). See Appendix B for a detailed description of the outcomes analyzed here. A + (or −) indicates a positive (or negative) correlation between the parameter and the outcome. The magnitude/strength of the correlation is given by the number of + (or −). The table recapitulates, whenever possible, the dynamics over time. The outputs with * are selected as examples to illustrate PRCC time courses (see Figure 6). See Appendix A for details on the parameters listed below.

	INFLAMMATION (LUNG)
PARAMETERS	Total Activated Macrophages	Tot Pet Hot*	Caseation/Necrosis	TNF*	IL10*
growthRateIntMtb		+ early1		+ + early
${\tau }_{{\mathrm{T}}_{\gamma }-\mathrm{CC}}$—chemokine threshold for Tγ recruitment		− − early		− early1	+ + +
τTcyt−CC—chemokine threshold for Tcyt recruitment		− − early		− early then +1	+ + +
τTreg−CC—chemokine threshold for Treg recruitment	−1	+ and then1		+ + early	− − −
k2—Naïve CD4 priming	+ +			− early1	+1
k4—CD4+ T precursor proliferation	+ + +				+1
k13—CD8+ T precursor proliferation	− − −	− − −	+ + + early − late	− − −	− − −
k14—CD8+ T differentiation—effector		+1		+1
k11—Naïve CD8 priming		−	+ + early − late	−1	−1

¹These PRCCs are below 0.3, so they are not shown in Figure 6.