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. 2017 Sep 28;11:1761–1767. doi: 10.2147/OPTH.S143428

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© 2017 Shen et al. This work is published and licensed by Dove Medical Press Limited

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Mean concentration of bimatoprost acid in the aqueous humor (A, B) and iris-ciliary body (C, D) of New Zealand White rabbits following once- or twice-daily administration of topical bimatoprost 0.01% or dual fixed-combination bimatoprost 0.01%/brimonidine 0.1% ophthalmic solutions. In the aqueous humor and iris-ciliary body, the lower limits of detection were 0.1 ng/mL and 1.75 ng/g, respectively. ^aAdministered once daily for 4 days. ^bAdministered twice daily on days 1 to 3, and once on day 4.