Table 2.
Incidence of Grade 1 conjunctival hyperemia in New Zealand White rabbits following BID or QD treatment with topical bimatoprost 0.01% or fixed-combination bimatoprost 0.01%/brimonidine 0.1%a
| Time-point | Bimatoprost 0.01%
|
Bimatoprost 0.01%/brimonidine 0.1%
|
||
|---|---|---|---|---|
| BID, n eyes (%) | QD, n eyes (%) | BID, n eyes (%) | QD, n eyes (%) | |
| Pre-dose | 0/28 (0) | 2/28 (7.1) | 0/28 (0) | 1/28 (3.6) |
| Day 1 | 18/28 (64.3) | 22/28 (78.6) | 5/28 (17.9) | 6/28 (21.4) |
| Day 2 | 1/28 (3.6) | 14/28 (50.0) | 0/28 (0) | 6/28 (21.4) |
| Day 3 | 0/28 (0) | 15/28 (53.6) | 0/28 (0) | 2/28 (7.1) |
| Day 4 | 0/16 (0) | 11/16 (68.8) | 2/16 (12.5) | 1/16 (6.3) |
| Cumulative frequency | 19/104 (18.3) | 64/104 (61.5) | 7/104 (6.7) | 15/104 (14.4) |
Note:
a
One report of Grade 2 conjunctival hyperemia in one eye of an animal treated with bimatoprost 0.01% QD on Day 3.
Abbreviations: BID, twice daily; QD, once daily.