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. 2017 Sep 27;13:2477–2487. doi: 10.2147/NDT.S145069

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© 2017 Li et al. This work is published and licensed by Dove Medical Press Limited

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Artesunate prevented rats from the clozapine-induced hepatic steatosis.

Notes: Rats were intraperitoneally given saline, clozapine, artesunate, or clozapine + artesunate for 6 weeks. At the end, the rats were deeply anesthetized with sodium pentobarbital and liver sample was taken and processed for hematoxylin–eosin staining. Representative images were from saline group (A), clozapine group (B), artesunate group (C), and clozapine + artesunate group (D) rats. The arrows in image B point to intracellular vacuoles where the lipid had been cleared. 200× magnification.

Abbreviation: CV, central vein.