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. Author manuscript; available in PMC: 2017 Oct 4.
Published in final edited form as: Nat Genet. 2016 Jun 6;48(7):768–776. doi: 10.1038/ng.3590

Figure 4. Clonal replacement in key driver genes.

Figure 4

(A) Mutations of seven key GBM drivers (EGFR, TP53, PDGFRA, PTEN, ATRX, NF1, and RB1) were replaced by different mutations in the same genes. (B–C) Mutational replacement in three different patients. Cancer cell frequency was estimated by Pyclone.