Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 25;40(5):1504–1510. doi: 10.3892/ijmm.2017.3150

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Hu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

T-cell immunoglobulin and mucin domain (TIM)4/TIM1 interaction increases silent information regulator 1 (SIRT1) expression in splenic CD4⁺ T cells. The RNA expression of SIRT1 in the nasal mucosa was evaluated by quantitative polymerase chain reaction. Splenic mononuclear cells in each group were collected and cultured with ovalbumin (10 ng/ml) for 3 days. CD4⁺ T cells were isolated by microbeads and SIRT1 expression was assessed by western blot analysis. (A) The bars indicate the SIRT1 mRNA levels in the nasal mucosa. (B and C) The immune blots show the levels of (B) phosphorylated Akt (p-Akt) and (C) the SIRT1 protein in splenic CD4⁺ T cells. The groups were annotated below the graphs. The data are presented as mean ± standard deviation. ^*P<0.05 vs. the control group. Ly294002, phosphoinositide 3-kinase/Akt inhibitor; AR, allergic rhinitis.