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. 2017 Sep 25;40(5):1504–1510. doi: 10.3892/ijmm.2017.3150

Figure 4.

Figure 4

Silent information regulator 1 (SIRT1) regulates CD4+ T-cell proliferation and apoptosis. The gated histograms indicate (A) splenic CD4+ T-cell proliferation and (B) splenic CD4+ T-cell apoptosis. (a1 and b1) Cells from the control group; (a2 and b2) cells from the allergic rhinitis (AR) group; (a3 and b3) cells from the AR group and CD4+ T cells were blocked by siRNA-T-cell immunoglobulin and mucin domain (TIM)1; (a4 and b4) cells from the AR group and CD4+ T cells were cultured with sirtinol (SIRT1 antagonist); (a5 and b5) cells from the AR group and CD4+ T cells were stimulated with resveratrol (SIRT1 agonist); (a6) carboxyfluorescein succinimidyl ester (CFSE)-positive control. (C) The bars show the summarized frequencies of (A). (D) The bars show the summarized frequencies of (B). Data are presented as mean ± standard deviation. *P<0.05 compared with control; #P<0.05 compared with AR.