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. 2017 Sep 25;40(5):1511–1519. doi: 10.3892/ijmm.2017.3152

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Transient receptor potential channel 1 (TRPC1) expression was downregulated in podocyte injury. (A) Predicted miR-135a target TRPC1 3′ untranslated region (UTR) in human and mouse species. (B) The protein level of TRPC1 was downregulated in the glomeruli isolated from BALB/c mice treated with adriamycin (ADR) in a time-dependent manner. (C) Quantitative analysis of the results of (B). (D) TRPC1 expression was inhibited in cultured MPC5 cells treated with ADR (5 μg/ml, 24 h) and transforming growth factor (TGF)-β (5 ng/ml, 24 h). (E) Quantitative analysis of the results of (D). ^*P<0.05 and ^**P<0.01 indicate statistically significant and highly statistically significant differences, respectively, compared with the control group.