Fig 8. Summary of key findings and proposed hypothetical scheme.

A. Summary table of key mitochondrial fission and fusion proteins affected by CS and CS/Tx. *Decrease in OMA1 expression equals increase in OMA1 activity [30;37]. B. Scheme representing a hypothetical mechanism of renal and mitochondrial injury during CS/Tx. Stress induced-mitochondrial protease OMA1 is over-activated when exposed to cold storage plus transplantation, which possibly contributes to proteolysis of critical fission and fusion proteins. This leads to fragmentation and damage of mitochondria and ultimately renal damage.