Table 3. Characteristics of thrombocytopenia in Gram positive and Gram negative sepsis.
| Overall (n = 460) | Gram positive (n = 412) | Gram negative (n = 48) | p-valuea | |
|---|---|---|---|---|
| Thrombocytopenia (<150*109/L)—n (%) | 226 (49) | 193 (47) | 33 (69) | 0.004 |
| Severity of thrombocytopenia | ||||
| - Mild (101–149*109./L)—n (%) | 64 (14) | 57 (14) | 7 (15) | |
| - Moderate (51–100*109/L)—n (%) | 70 (15) | 64 (16) | 6 (13) | |
| - Severe (21–50*109/L)—n (%) | 58 (13) | 54 (13) | 4 (8) | |
| - Very severe (≤20*109/L)—n (%) | 34 (7) | 18 (4) | 16 (33) | |
| Days until platelet count >100*109/L (days)b—median (IQR) | 6.0 (4.0–7.0) | 5.0 (4.0–7.0) | 7.0 (5.3–12.8) | 0.009 |
| Lowest platelet count (*109/L)—median (IQR) | 63.0 (28.0–108.0) | 66.0 (31.8–110.3) | 28.0 (13.0–85.5) | 0.002 |
| Platelet count decrease (*109/L)—median (IQR) | 111.5 (58.8–164.3) | 104.0 (55.0–151.0) | 153.0 (68.8–222.5) | 0.012 |
| Day of onset after infection—median (IQR) | 1.0 (1.0–1.0) | 1.0 (1.0–2.0) | 1.0 (1.0–1.0) | 0.157 |
| Proportion of neonates receiving platelet transfusion—n (%) | 86 (19) | 67 (16) | 19 (40) | <0.001 |
| Number of platelet transfusions per neonatec— median (IQR) | 2.0 (1.0–3.0) | 2.0 (1.0–3.0) | 3.0 (1.0–7.0) | 0.009 |
a p-value of comparison between Gram positive and Gram negative sepsis.
bRecorded in neonates with lowest platelet count <100*109/L, n = 137 in Gram positive sepsis and n = 26 in Gram negative sepsis.
cRecorded in neonates requiring platelet transfusions.