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. 2017 Oct 4;12(10):e0186006. doi: 10.1371/journal.pone.0186006

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© 2017 Yokoi et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (A) Forrest plot. RR, risk ratio; CI, confidence interval. (B) Trial sequential analysis. Risk of type I error was maintained at 5% with 90% power. The variance was calculated from data obtained from the trials included in this meta-analysis. A clinically meaningful anticipated RR of the early-period POV was set at 0.75.