. 2017 Oct 4;12(10):e0186006. doi: 10.1371/journal.pone.0186006

Table 2. Ondansetron subgroup analysis.

	Summary		Ondansetron dose
	Summary		4 mg		8 mg		p value for subgroup difference
	RR (95% CI)	I²	RR (95% CI)	I²	RR (95% CI)	I²	p value for subgroup difference
Early PON	0.82 (0.69 to 0.98)	31%	0.65 (0.52 to 0.81)	0%	1.01 (0.84 to 1.21)	0%	0.002
Late PON	0.76 (0.65 to 0.89)	20%	0.68 (0.56 to 0.84)	1%	0.85 (0.65 to 1.09)	12%	0.20
Next day PON	0.69 (0.57 to 0.84)	0%	0.69 (0.55 to 0.89)	8%	0.63 (0.39 to 1.01)	0%	0.72
Early POV	0.78 (0.63 to 0.98)	0%	0.61 (0.35 to 1.06)	0%	0.87 (0.66 to 1.13)	0%	0.26
Late POV	0.57 (0.45 to 0.72)	0%	0.57 (0.35 to 0.93)	0%	0.67 (0.48 to 0.94)	0%	0.61
Next day POV	0.61 (0.43 to 0.86)	0%	0.50 (0.33 to 0.76)	0%	0.57 (0.25 to 1.31)	0%	0.76

PON, postoperative nausea; POV, postoperative vomiting; RR, risk ratio; CI, confidence interval.