Table 3.

Receiver operating characteristic (ROC) curve areas and T-test p-values for the ten serum N-glycans considered for inclusion in an optimized composite score for diagnostic discrimination of cancer cases and controls.

Monosaccharide composition				Fold change	T-test	ROC	Inclusion in composite
Hex	HexNAc	Fuc	NeuAc	(Control to cancer)	(p-Values)	(AUC)
5	6	4		−8.56	4.47 × 10−12	0.87	✓
6	3			−1.55	3.09 × 10−11	0.85	✓
5	5	2	1	−2.46	5.56 × 10−11	0.87	✓
5	5			−1.44	1.52 × 10−10	0.77	✓
7	6	1	2	3.36	1.15 × 10−9	0.85	✓
3	2			−1.63	1.18 × 10−8	0.83
6	5	1	2	2.54	3.77 × 10−8	0.82	✓
5	4	1		−1.58	6.22 × 10−8	0.82
6	3	1		−2.80	1.17 × 10−6	0.79	✓
4	4			−1.37	6.19 × 10−6	0.86
Composite index:				−2410	2.46 × 10−20	0.96

Glycan compositions were assigned based on accurate mass. Fold change is a measure of the change in glycan abundances between healthy controls and cancer cases. Positive fold changes denote the ratio of cancer to control, whereas negative fold changes denote the ratio of control to cancer. AUC denotes area under the ROC curve (out of a maximum of 1.0000).