Fig. 2.

Grip1/2 DKO mice show increased sociability and preference for social novelty.

Panel a. Sociability. During the first 10 min, individual test mouse was allowed to freely interact with an empty cage versus a cage with a stranger mouse in the testing chamber. Total time of social interaction (in second) of the test mouse with these two cages was measured. Both WT and Grip1/2 DKO mice spent significantly more time interacting with the stranger mouse versus empty cage (t-test, p < 0.001). Grip1/2 DKO mice exhibit a significant increase in sociability as compared to WT control mice (two-way ANOVA, (F_(1,72) = 11.34, p < 0.01). Panel b. Preference for Social Novelty. During the second 10 min, individual test mouse was allowed to freely interact with the cage with a familial mouse and cage with a stranger mouse in the testing chamber. Total time of social interaction (in second) of the test mouse with these two cages was measured. The mean and SEM for WT (n = 10) and Grip1/2 DKO (n = 10) were shown. Both WT and Grip1/2 DKO mice spent significantly more time in social interaction with the novel mouse than with the familiar mouse (p < 0.01 and p < 0.001). Grip1/2 DKO mice exhibit a significant increase in the preference of social novelty as compared to WT control mice (two-way ANOVA test, F_(1,72) = 13.04, p < 0.001). Data presents as mean ± SEM. **, p < 0.01; ***, p < 0.001)