Fig. 3.

Grip1/2 DKO mice show increased dyadic male–male social interactions.

Panel a. The test and stranger mice were allowed to freely interact for 5 min in a test chamber. The total time of nonaggressive social interactions including sniffing and following was measured. Three testing cohorts including WT–WT (10 pairs), WT-DKO (10 pairs) and DKO–DKO (5 pairs) were studied. Panel b. Total events of interaction for the three testing cohorts were determined. Note the WT-DKO and DKO–DKO cohorts of mice show a significant increase in nonaggressive social interaction as compared to the WT–WT cohort (t-test, p < 0.01). Data presents as mean ± SEM. **, p < 0.01; ***, p < 0.001)