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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Radiat Res. 2017 Jul 19;188(3):303–313. doi: 10.1667/RR14662.1

FIG 4.

FIG 4

Likelihood of progression [positive predictive value (PPV)] of voxels NAV at baseline progressing into the NEL or CEL at recurrence, as function of voxel parameters. Panels A and B demonstrate the PPV of voxels using the discrete model, whereby voxels are subdivided by their distance from the primary tumor (panel A: 0–2 cm; and panel B: 2–4 cm) and their CNI values (top). Within each group of voxels with similar CNI values and distance from the primary tumor, the PPV is calculated for voxels as a function of ADC and FA. Panel C shows the results of the continuous model [Eq. (1)], whereby the effect of a single parameter on the PPV is illustrated by sweeping through a range of values while holding all other parameters constant. This is done for a voxel at 1 and 3 cm, illustrating the strong effect of distance on likelihood of recurrence.