Table 2.

Effect of obesity on wound healing

Local wound conditions	Associated diseases and conditions	Factors altering immune and inflammatory responses
1. Decreased vascularity in adipose tissue	1. Hard to reposition	1. Adipokines: leptin, adiponectin, resistin
2. Skin folds harbour micro-organisms	2. Coronary heart disease	2. Cytokines: TNF-alpha, IL-1, IL-6, IL-8, IL-10
3. Friction caused by skin on skin	3. Atherosclerosis	3. Chemokines: IL-8, MCP-1, IP-10
4. Increased wound tension	4. Type 2 diabetes
5. Increased tissue pressure	5. Cancer
6. Hematoma and seroma formation	6. Hypertension
7. Venous hypertension	7. Dyslipidemia
	8. Stroke
	9. Respiratory problems

MCP monocyte chemoattractant protein-1, IP-10 interferon-gamma-inducible protein 10