Table 2.

Summary of signaling pathways and biological processes in disease models cited within affected by niclosamide.

Pathway or process affected by Niclosamide	Tape worm	Cancer	Bacteria	Virus	Metabolic syndrome	Artery constriction	Endo-metriosis	Neuro-pathic pain	Rheumatoid arthritis	Graft-versus-host disease	Systemic sclerosis
Uncoupling of oxidative phosphorylation	4–7	9			79	82
Wnt		9, 11, 19, 23-25, 29, 35, 44, 45, 55						87		92	94
mTORC1		13, 29
STAT3		14, 15, 31, 37, 38, 50					84			92	94
NF-κB		29, 34, 35					84		89
Notch		26, 29, 33								92
AKT/ERK/Src		20								92	94
AR-V7		49
C-Fos, C-Jun, E2F1, c-Myc		41
mGluRs								86
Metabolic pathways		42
ROS		34
Mitochondria		52, 55				82
pH	78	13, 52	58	70