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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Cancer Discov. 2017 Jun 2;7(10):1154–1167. doi: 10.1158/2159-8290.CD-16-0850

Figure 5. CART123 establish long-term immunological memory in mice with HL.

Figure 5

A. Experiment schema: mice previously treated with CART123 and experiencing a long-term remission were rechallenged at day 250 with HL cells (HDLM-2). As a control a tumor-naïve group of mice were also injected with the same HL cells. B. HL cells only engrafted and grew in tumor-naïve mice while long-term surviving mice (post-CART123) were able to control disease growth. C. A re-expansion of CART123 cells was observed in mice previously treated with CART123. D. An improved overall survival was observed in mice with previous exposure to CART123.