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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Cancer Discov. 2017 Jun 2;7(10):1154–1167. doi: 10.1158/2159-8290.CD-16-0850

Figure 6. CART123 are resistant to inhibition by M2-macrophages.

Figure 6

A. In a 5-day CFSE proliferation assay, CART123 are completely resistant to HL-polarized macrophage mediated inhibition. B. CART123 cells rapidly (day 1) recognize M2-macrophages, forming clusters around macrophages and clearing them by day 5 as shown by phase contrast microscopy (20X) and flow cytometry, respectively. C. CART19 but not CART123 cytokine secretion was significantly reduced in the presence of M2 (IL-4 polarized) macrophages in vitro.