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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Mol Cancer Ther. 2017 Jun 15;16(10):2191–2200. doi: 10.1158/1535-7163.MCT-16-0907

Figure 4. 225Ac-IA-TLs permeabilized BBB in immunocompetent mice in a dose dependent manner.

Figure 4

(A) Dose escalation study showed a dose dependent effect of 225Ac-IA-TLs on BBB permeability in immunocompetent mice intracranially infused with 225Ac-IA-TLs (n=15; n=5/dose) indicated by contrast enhancement on MRI. (B) Dose dependent effect of 225Ac-IA-TLs on BBB permeability was also confirmed by the extravasation of intravenously injected Evans Blue dye. Immunocompetent mice intracranially infused with saline showed no BBB opening (n=5). Data represented as mean +/− SEM. Student’s t-test and One-way ANOVA was performed to assess differences between experimental groups (*p< 0.05(significant)).