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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Hum Pathol. 2017 May 24;67:1–10. doi: 10.1016/j.humpath.2017.05.010

Fig. 7.

Fig. 7

Immunohistochemical findings typical of a high-grade MPNST. A. Only a small number of slender S100-positive Schwann cells are present mostly representing elements of residual neurofibroma. B. This example shows Schwannian differentiation as demonstrated by extensive SOX10 positivity in tumor cells. C. Tumor cells have a loss of p16 expression, with non-neoplastic cells positive. D. There is a loss of expression of trimethylated lysine 27 in histone 3 (H3K27me3) in tumor nuclei. Lymphoid cells and endothelia serve as internal positive controls.