Table 1.
Hemodynamic Data for the Monocrotaline Model
| Control (n = 5) |
MCT-Sham (n = 9) |
MCT-RD (n = 9) |
p Value |
||
|---|---|---|---|---|---|
| Control vs. MCT | MCT vs. RD | ||||
| RV end-systolic pressure (mm Hg) | 27 ± 2.5 | 66 ± 2.9 | 61 ± 2.3 | <0.001 | 0.35 |
| RV end-diastolic pressure (mm Hg) | 2.8 ± 0.6 | 3.9 ± 0.6 | 3.3 ± 0.3 | 0.57 | 0.97 |
| dP/dt maximum (mm Hg/s) | 1,681 ± 218 | 2,732 ± 170 | 2,554 ± 126 | <0.001 | 0.42 |
| dP/dt minimum (mm Hg/s) | –1,293 ± 174 | –2,366 ± 141 | –2,405 ± 100 | <0.001 | 0.83 |
| Tau (ms) | 11 ± 2.5 | 13 ± 1.0 | 12 ± 0.4 | 0.32 | 0.46 |
| Systolic blood pressure (mm Hg) | 102 ± 6.6 | 88 ± 3.1 | 75 ± 3.3 | 0.15 | 0.03 |
| Diastolic blood pressure (mm Hg) | 67 ± 7.9 | 65 ± 2.6 | 51 ± 3.2 | >0.999 | 0.03 |
| SVR (mm Hg·min·ml-1) | 0.6 ± 0.1 | 1.9 ± 0.3 | 1.1 ± 0.1 | 0.002 | 0.01 |
| Heart rate (beats/min) | 300 ± 11.4 | 317 ± 5.5 | 300 ± 13.7 | >0.999 | 0.30 |
Values are mean ± SEM. One-way ANOVA followed by Bonferroni correction.
MCT = monocrotaline; RD = renal denervation; RV = right ventricle; SVR = systemic vascular resistance; Tau = isovolumic relaxation constant.