Table 2.
Hemodynamic Data for the Sugen + Hypoxia Model
| Control (n = 6) |
SuHx-sham (n = 10) |
SuHx-RD (n = 10) |
p Value |
||
|---|---|---|---|---|---|
| Control vs. SuHx | SuHx vs. RD | ||||
| RV end-systolic pressure (mm Hg) | 24 ± 0.93 | 60 ± 3.3 | 56 ± 3.3 | <0.001 | 0.39 |
| RV end-diastolic pressure (mm Hg) | 1.9 ± 0.09 | 2.7 ± 0.4 | 3.3 ± 0.4 | 0.56 | 0.22 |
| dP/dt maximum (mm Hg/s) | 1,149 ± 40 | 2,515 ± 142 | 2,733 ± 210 | <0.001 | 0.34 |
| dP/dt minimum (mm Hg/s) | –953 ± 43 | –2,092 ± 146 | –2,267 ± 202 | <0.001 | 0.43 |
| Tau (ms) | 5.1 ± 0.45 | 10.1 ± 0.79 | 10.7 ± 0.88 | <0.001 | 0.63 |
| Systolic blood pressure (mm Hg) | 86 ± 3.5 | 90 ± 6.71 | 80 ± 4.1 | >0.999 | 0.17 |
| Diastolic blood pressure (mm Hg) | 59 ± 3.2 | 66 ± 7.1 | 54 ± 3.9 | >0.999 | 0.12 |
| SVR (mm Hg·min·ml–1) | 0.7 ± 0.03 | 1.3 ± 0.2 | 0.9 ± 0.09 | 0.01 | 0.03 |
| Heart rate (beats/min) | 261 ± 8.5 | 274 ± 10.1 | 249 ± 9.5 | >0.999 | 0.21 |
Values are mean ± SEM. One-way ANOVA followed by Bonferroni correction.
SuHx = sugen + hypoxia; other abbreviations as in Table 1.