Table 3.

Yield of genetic testing by time period

	Pre-protocol time period			Post-protocol time period
	Completed	Abnormal	Abnormal (%)	Completed	Abnormal	Abnormal (%)
Karyotype	307	56	18	33	25	76
22q11.2 testing	243	23	9	23	6	26
Microarray	292	70	24	94	21	22

The pre-protocol time period had increased utilization of Karyotype and 22q11.2 testing with low yield, but in the post-protocol period these tests were used more efficiently as reflected by an increased yield in abnormal test results. The rate of abnormalities identified by microarray showed no significant difference between the pre-protocol and post-protocol period showing that expanded utilization increases number of patients identified with chromosomal anomalies