Table 2.

Summary of genome-wide significant and suggestive (<5 × 10⁻⁷) associations in GWAS meta-analysis

Chr.a	Position	Nearest gene	SNP	EA/RAb	EAFc	Stage 1 + 2 (N = 3399/4764)
						OR (95% CI)d	P value	Direction	P het	I 2
22	37,728,254	CYTH4	rs739187	T/C	0.27	1.23 (1.16–1.30)	7.83E−09	++++++	0.24	26.0
22	37,722,301	CYTH4	rs4821628	A/G	0.75	0.81 (0.74–0.88)	8.86E−09	−−−−−−	0.22	29.0
22	37,726,660	CYTH4	rs713939	T/C	0.28	1.22 (1.15–1.29)	1.37E−08	++++++	0.30	17.8
22	37,719,004	CYTH4	rs5995416	T/C	0.29	1.21 (1.14–1.28)	3.44E−08	++++++	0.40	1.3
22	37,717,946	CYTH4	rs4821627	T/C	0.29	1.21 (1.14–1.27)	5.86E−08	++++++	0.33	13.1
3	5,348,595	EDEM1	rs55768811	A/T	0.91	0.76 (0.66–0.87)	2.62E−07	−−−−−−	0.72	0
8	75,119,342	JPH1	rs6472827	T/C	0.07	0.76 (0.65–0.86)	3.89E−07	−−−−−−	0.99	0
3	5,346,825	EDEM1	rs6804817	T/G	0.09	1.31 (1.20–1.41)	4.18E−07	++++++	0.64	0
3	5,348,095	EDEM1	rs62255982	T/C	0.09	1.31 (1.21–1.42)	4.39E−07	++++++	0.70	0
22	37,736,406	CYTH4	rs34377599	G/GC	0.70	0.78 (0.69–0.88)	4.62E−07	−−−?−−	0.54	0
8	4,441,780	CSMD1	rs11987640	C/G	0.20	0.81 (0.73–0.89)	4.85E−07	?−−−++	0.01	68.8
8	4,441,757	CSMD1	rs11987636	A/G	0.20	0.81 (0.73–0.89)	4.94E−07	?−−−++	0.01	68.8

Boldface indicates genome-wide significant p values

^aChromosome

^bEffect allele/reference allele

^cEffect allele frequency

^dOdds ratio per additional effect allele (95% confidence interval)