Table 1.
Area under receiver operating curves of circulating bone biomarkers to distinguish high and low bone turnover from nonhigh and nonlow bone turnover, respectively, as assessed by BFR/BS [27] (approval pending)
| Blood sample marker | N | AUROC (95% CI) | Best cut off |
|---|---|---|---|
| Low vs non low | |||
| iPTH (pg/ml) | 280 vs 196 | 0.701 (0.653–0.750) | 103.8 |
| wPTH (pg/ml) | 260 vs 180 | 0.712 (0.662–0.761) | 48.0 |
| bALP (U/l) | 273 vs 190 | 0.757 (0.713–0.801) | 33.1 |
| P1NP (ng/ml) | 280 vs 1197 | 0.650 (0.599–0.701) | 498.9 |
| Combined iPTH + bALP | 272 vs 188 | 0.718 (0.670–0.767) | NA |
| Combined wPTH + bALP | 257 vs 174 | 0.743 (0.695–0.790) | NA |
| High vs non high | |||
| iPTH (pg/ml) | 81 vs 395 | 0.724 (0.663–0.786) | 323.0 |
| wPTH (pg/ml) | 75 vs 365 | 0.678 (0.611–0.746) | 61.4 |
| bALP (U/l) | 77 vs 386 | 0.711 (0.655–0.767) | 42.1 |
| P1NP (ng/ml) | 81 vs 396 | 0.743 (0.689–0.797) | 621.1 |
| Combined iPTH + bALP | 76 vs 384 | 0.718 (0.658–0.779) | NA |
| Combined wPTH + bALP | 72 vs 359 | 0.691 (0.628–0.725) | NA |
AUROC area under the receiver operating characteristic curve, bALP bone-specific alkaline phosphatase, BFR/BS bone formation rate/bone surface, CI confidence in-terval, iPTH intact parathyroid hormone, NA not available, P1NP amino-terminal propeptide of type 1 procollagen, wPTH whole parathyroid hormona