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Histopathology of brain lesion. (A, B) Dendritic cell infiltration with mixed inflammation including histiocytes, lymphocytes, plasma cells, and rare eosinophils (H&E 200× and 400×). (C) Langerhans cells lack CD1a expression (200×). (D) Langerin immunohistochemistry demonstrates Langerhans cells predominantly involving the Virchow–Robin spaces (200×).
