Skip to main content
. 2017 Sep 8;49(9):e374. doi: 10.1038/emm.2017.130

Figure 6.

Figure 6

Inhibition of FGFR1 renders the cancer cells susceptible to cisplatin-mediated cytotoxicity. (a) Schematic of the therapy regimen in mice implanted with CaSki P3 CR cervical cancer cells. (b) Cancer growth and (c) survival of mice inoculated with CaSki P3 CR cells treated with the indicated regimens (8 mice per group). (d) Cancer mass of mice at 21 days after inoculation. (e) Western blot analysis of pFGFR, pERK and Bim expression in mice administered either PBS or SSR128129E in the presence or absence of cisplatin. β-actin was included as an internal loading control. The numbers below the blot images indicate the expression as measured by fold change. (f) Flow cytometry analysis of the percentage of apoptotic (active caspase-3+) cells in the cancer tissues of mice treated with either PBS or SSR128129E in the presence or absence of cisplatin. Error bars represent the s.d.'s from the mean. *P<0.01, **P<0.005, ***P<0.001.