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. 2017 Sep 29;49(9):e381. doi: 10.1038/emm.2017.144

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Resveratrol treatment ameliorates lupus nephritis and reduces fibrosis and immune complexe (IC) deposition in the kidneys of MRL/lpr mice. (a) Kidneys from control (n=4) and resveratrol-treated (n=4) MRL/lpr mice were sectioned and stained with H&E and Masson’s trichrome solutions. Sections of collagen-positive areas (shown in blue) revealed by Masson’s trichrome staining were quantified as the average percentage of each high-power field (HPF) (>5 HPFs/section/mouse, >6 glomeruli/HPF) using MetaMorph software for control (n=4) and resveratrol-treated (n=4) MRL/lpr mice. Areas of collagen-deposition at the glomerular and tubulo-interstitial space were quantified separately. (b) Deposition of IgG- and IgM-ICs in the glomeruli on renal sections of control (n=3) and resveratrol-treated (n=3) MRL/lpr mice. Three mouse kidneys of each group were analyzed. Quantification was performed, analyzed and presented as in a. (c) Sections of control (n=3) and resveratrol-treated (n=3) mice were stained and quantified for the expression of Sirt1 and p65 NF-κB (K310) as in a. (d) Before (17 weeks of age) and after (20 weeks of age) treatment, serum creatinine levels were measured by enzyme-linked immunosorbent assay to compare control (n=9) and resveratrol-treated (n=13) mice. Scale bars, 50 μm. *P<0.05, **P<0.01, ***P<0.001.