Table 1. Published cases of Vim DBS for OT.
| Author | Target | Outcome | Follow‐up in Months | Active Contact (a), Target (t), or Lead Tip Location (l) in Planes x, y, z | Stimulator Settings |
|---|---|---|---|---|---|
| Espay et al.4 | Vim bilateral | Improved standing time from 30 s to >3 min | >18 | L: –14.2, 7.2, 2.3 (a); R: 12.0, 4.9, 0.3 (a) | L: 0+2–, 4.0 V, 90 µs, 185 Hz; R: C+1–, 4.0 V, 60 µs, 185 Hz |
| Espay et al.4 | Vim unilateral (right) | Near resolution of symptoms for 3 months, then return to presurgical level of function | 18 | R: 13.5, 7.8, 1.7 (a) | R: 3+1–, 1.5 V, 90 µs, 160 Hz |
| Guridi et al.5 | Vim bilateral | “marked cessation of tremor” | 48 | L: –15, 4–5, 1 (t); R: 15, 4–5, 1 (t) | L: C+0–, 2.0 V, 60 µs, 130 Hz; R: C+4–, 2.0 V, 60 µs, 130 Hz |
| Magarinos‐Ascone et al.6 | Vim bilateral | “The patient could stand up normally without any help or leg tremor” | 12 | – | L: bipolar?, V, 90 µs, 185 Hz; R: bipolar?, V, 90 µs, 185 Hz |
| Yaltho et al.7 | Vim bilateral | Improved standing time from 30 s to >4 min | 6 | – | L: C+0–3–, 2.1 V, 90 µs, 135 Hz; R: C+0–1–3–, 2.6 V, 90 µs, 170 Hz |
| Lyons et al.8 | Vim bilateral | Improved standing time from 20 s to >7 min | 30 | 11.5 mm lateral to 3rd ventricle (t) | L: 6+4–5–, 2.2 V, 90 µs, 185 Hz; R: 1+0–, 2.7 V, 90 µs, 185 Hz |
| Contarino et al.9 | Vim bilateral | Initially marked symptomatic improvement, although benefit lessened to no “optimal clinical improvement” | 60 | L: –15.2, 7.2, 0.8 (l); R: 12.8, 8.3, 1.8 (l) | – |
| Hassan et al.2 | Vim bilateral | “improved standing ability and reduction of OT severity” | 36 | – | – |
| Hassan et al.2 | Vim bilateral | “improved standing ability and reduction of OT severity” | 36 | – | – |
| Coleman et al.3 | Vim bilateral | Improved standing time from 50 s to 15 min | 16 | L: –14.8, 8.6, 1.5 (a); R: 12.8, 7.9, 3.8 (a) | L: 1+2–, 3.0 V, 60 µs, 140 Hz; R: 9+10–, 2.6 V, 60 µs, 140 Hz |
| Coleman et al.3 | Vim bilateral | Improved standing time from <30 s to >4 min | 7 | L:–15.4, 9.7, 7.8 (a); R: 10.8, 5.4, –1.2 (a) | L: 2–3+, 1.9 V, 60 µs, 170 Hz; R: C+8–, 2.1 V, 60 µs, 170 Hz |
| Current case | Vim bilateral | Improved standing time from 3 min to 5 min | 12 | L: –12, 6, 3.5 (a) 10.5 mm lateral to 3rd ventricle (t); R: 12.6, 6, 3.5 (a) 11.5 mm lateral to 3rd ventricle (t) | L: –1+3, 2.05 mA, 75 µs, 130 Hz; R: –1+3, 2.05 mA, 75 µs, 130 Hz |
Abbrevitation: DBS, Deep Brain Stimulation; OT, Orthostatic Tremor; Vim, Ventral Intermediate Nucleus.