Fig. 6.

Effect of Rg3-RGE on MAPK phosphorylation in collagen-activated platelets. Washed platelets were pretreated with Rg3-RGE and stimulated with collagen. After the reaction was terminated, protein was extracted from platelets and analyzed for the phosphorylation of MAPKs by immunoblot. Immunoblot images are representative of at least three independent experiments. *p < 0.05, **p < 0.01, and ***p < 0.001 compared to the agonist-treated group. ERK1/2, extracellular stimuli-responsive kinase 1/2; JNK, Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MKK4, mitogen-activated protein kinase kinase 4; RGE, Rg3-enriched red ginseng extract.