Fig. 8.

Analysis of thrombus formation. Mice were pretreated with Rg3-RGE by oral injection for 3 days. (A) Two hours after the final Rg3-RGE dose, mice were challenged with a collagen plus epinephrine mixture and checked for survival at 15 min. (B) Representative histology images (100×) of H&E-stained lungs from mice treated with (a) vehicle, (b) collagen and epinephrine mixture, and (c) with Rg3-RGE 50 mg/kg and collagen and epinephrine mixture. Arrows indicate occlusive thrombi in pulmonary vessels. ***p < 0.001 compared to the agonist-treated group. H&E, hematoxylin and eosin; Rg3-RGE, Rg3-enriched red ginseng extract.