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. 2016 Nov 10;41(4):534–539. doi: 10.1016/j.jgr.2016.10.005

Table 2.

Top 10 potential targets of ginsenosides according to docking scores

PDB ID Target name Native ligand
Ginsenoside
Implicated by experiment2) Reference
Docking score1) Type Docking score
3OS3 Dual specificity mitogen-activated protein kinase kinase 1 −7.278 Rf −12.681 Yes [19]
3O96 RAC-alpha serine/threonine-protein kinase −10.836 Rs3 −11.394 No
1MCH Immunoglobulin lambda light chain dimer (Mcg) −7.988 Rf −10.217 No
2ITX Epidermal growth factor receptor precursor −5.256 R2 −10.090 Yes [20]
1TUI Elongation factor 1-alpha −8.649 Ro −9.718 No
1ETT Thrombin −8.384 Rg1 −9.566 Yes [21]
3FGU Glucokinase −3.853 Ro −9.346 Yes [22]
1DHT Estrogenic 17-beta hydroxysteroid dehydrogenase −5.785 Rh5 −9.306 No
2PVR Casein kinase II subunit alpha −5.499 R2 −9.240 No
1OL6 Aurora kinase A −8.342 Re −9.211 No
1)

Docking scores from redocking of receptor proteins and native ligands of PDB entries

2)

Whether or not there is an experimental result of the particular ginsenosides and the target in the literature