Table 2.
Top 10 potential targets of ginsenosides according to docking scores
| PDB ID | Target name | Native ligand |
Ginsenoside |
Implicated by experiment2) | Reference | |
|---|---|---|---|---|---|---|
| Docking score1) | Type | Docking score | ||||
| 3OS3 | Dual specificity mitogen-activated protein kinase kinase 1 | −7.278 | Rf | −12.681 | Yes | [19] |
| 3O96 | RAC-alpha serine/threonine-protein kinase | −10.836 | Rs3 | −11.394 | No | |
| 1MCH | Immunoglobulin lambda light chain dimer (Mcg) | −7.988 | Rf | −10.217 | No | |
| 2ITX | Epidermal growth factor receptor precursor | −5.256 | R2 | −10.090 | Yes | [20] |
| 1TUI | Elongation factor 1-alpha | −8.649 | Ro | −9.718 | No | |
| 1ETT | Thrombin | −8.384 | Rg1 | −9.566 | Yes | [21] |
| 3FGU | Glucokinase | −3.853 | Ro | −9.346 | Yes | [22] |
| 1DHT | Estrogenic 17-beta hydroxysteroid dehydrogenase | −5.785 | Rh5 | −9.306 | No | |
| 2PVR | Casein kinase II subunit alpha | −5.499 | R2 | −9.240 | No | |
| 1OL6 | Aurora kinase A | −8.342 | Re | −9.211 | No | |
Docking scores from redocking of receptor proteins and native ligands of PDB entries
Whether or not there is an experimental result of the particular ginsenosides and the target in the literature