Figure 6.
Disrupting the KLF9–JNK3 interaction or expressing KLF9 S106/110A mutants enhance optic nerve axon regeneration 2 weeks after optic nerve injury. A, Images of Brn3a-positive cells in retinal segments from different groups. Scale bar, 100 μm. B, Quantification of RGC survival showed no significant differences among all groups. C, Images of merged optic nerve sections showing CTB-labeled regenerating axons. Scale bar, 200 μm. Asterisks indicate lesion sites. D, Significantly more regenerating fibers were observed in JBD-P, KLF9S106/110A, and KLF9ΔJBD treated animals than in control animals. *p < 0.05, **p < 0.01, one-way ANOVA; n = 4. Error bars indicate SEM.